Lynn Stothers, MD, Andrew Macnab, MD.
University of British Columbia, Vancouver, BC, Canada
Presented on May 22, 2007
Introduction and Objective: Near Infrared Spectroscopy (NIRS) is a portable, non-invasive means of measuring changes in detrusor deoxyhemoglobin (Hb), oxyhemoglobin (HbO2) and Cytochrome AA3 (Cyt), the respiratory enzyme residing within the mitochondria of the detrusor. The objective of this study was to measure Hb and HbO2 with NIRS during the natural filling and voiding cycle in asymptomatic adults.
Methods: 15 male (18-60 years) and 15 female (20-60 yrs) adult volunteers participated. All had no history of urinary tract symptoms, normal flow patterns for age, and had residual urine measurements by ultrasound of less than 50cc. NIRO-300 (Hamamatsu, Japan) spectrophotometer optodes were positioned suprapubically throughout filling and emptying. During voiding NIRS and uroflow data was recorded simultaneously at 6Hz as subjects emptied into a conventional uroflowmeter. During filling, subjects lay supine with minimal body movement and were provided water ad lib until bladder capacity was reached. A second study with simultaneous uroflow and NIRS followed by residual urine was recorded.
Results: During emptying, mean NIRS changes, in μmol*L-1 , relative to the pre-voiding baseline were: HbO2 -8.38 in women vs 7.61 in men; Hb -0.76 in women vs 4.42 in men. During voiding there is a change in the concentration of oxy and deoxy Hb. An example for men is shown below.
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